Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective TYLENOL [Acetaminophen APAP]why it may cause harm Tylenol should likely be avoided in excess by genetically vulnerable children. GENETICALLY VULNERABLE likely meanschildren with limited supplies of GLUTATHIONE. The problem with TYLENOL