Tylenol's Impact on Glutathione and Liver Damage Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? The parent compounds of acetaminophen (US market in 1955 in the US as Tylenol and other products) were first discovered in 1886 (acetanilide) and 1887 (phenacetin). These were the earliest synthetic fever Parents ask me this all the time: Motrin or Tylenol for fever? Here's my pediatric naturopathic perspective: Motrin treats inflammation, which often drives fever It lasts longer, so fewer doses