Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Consultant360 Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Happy Wednesday! , In this video, a patients labial melanotic macule (a benign pigmented lesion) is being treated with liquid nitrogen. Labial melanotic macules are flat and asymmetrical with a Congenital Melanocytic Macule of the Tongue in a Newborn Cureus