Frontiers Glycine Histidine Lysine (GHK) Alleviates Astrocytes Injury of Intracerebral Hemorrhage via the Akt miR 146a 3p AQP4 Pathway Attenuation of Response to Repeated Drug Administration: A Proposal for Differentiating Tachyphylaxis and Tolerance The Journal of Pharmacology and Experimental Therapeutics Rigid flexible nanocarriers loaded with active peptides for antioxidant and anti inflammatory applications in skin ScienceDirect 2021A12 Define the terms tolerance and tachyphylaxis. Discuss the different mechanisms by which tolerance can develop, giving examples where appropriate.