BPC 157 Benefits, Dosage & Before After Results Peptide Therapy in Brandon & Lakeland, FL BPC 157, TB 500 & GHK Cu Peptide side effects no one talks about BPC 157 headaches. TB 500 fatigue. CJC Ipamorelin water retention. Most people quit. But 90% of the time it's the protocol, not the peptide. Peptides are often well tolerated, but they can still cause temporary reactions while the body adapts. Some commonly reported effects include: BPC 157 headaches, nausea, increased appetite TB 500