Pigmented Lesions of the Oral Mucosa Pocket Dentistry Freckle on Lip: Meaning, Causes and Is It Dangerous? (Labial Melanotic Macule) La Bouche Parfaite Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Pigmented Lesions of the Oral Cavity Oral and Maxillofacial Surgery Clinics