Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Glutathione, Tylenol, and Vaccines: What Parents Need to Know Lotus Homeopathy, Inc.