The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications Peptide Inhibitors Targeting FOXO4 p53 Interactions and Inducing Senescent Cancer Cell specific Apoptosis Journal of Medicinal Chemistry FOXO4 DRI Anti Aging: Approach to Cellular Rejuvenation Mokiner The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications
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foxo4-dri news The FOXO4 peptide in a DRI conformation (D-amino acids in a retro-reversed sequence), henceforth named FOXO4-DRI, competes with FOXO4 for p53 binding in a dose-dependent manner and doing so with higher affinity