Glutathione deficiency can lead to a variety of signs and symptoms that affect your overall health. Here are some common signs to look out for: 1. **Increased Dark Spots** Glutathione Supporting Your Immune System Naturally with Glutathione Dr Hagmeyer Frontiers Glutathione deficiency in the pathogenesis of SARS CoV 2 infection and its effects upon the host immune response in severe COVID 19 disease Frontiers Glutathione: Pharmacological aspects and implications for clinical use in non alcoholic fatty liver disease