Glutathione IV Therapy: Benefits, Side Effects, and More Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Deficient Glutathione in the Pathophysiology of Mycotoxin Related Illness How Much is Too Much? Mastering Your Glutathione Injection Dosage Per Week