What Happens If You Inject B12 Wrong: 6 Red Flags Injecting substances can expose individuals that use injection drugs to serious harm, but understanding the difference between safer and more harmful sites can help reduce these potential dangers. Here's a breakdown of Subcutaneous (SC) and Intramuscular (IM) Injections Must Knows for Subcutaneous administration: Pinch skin with non dominant hand and hold syringe with dominant hand Always inject: 2 inches away from umbilicus (for abdomen) 3 inches Injection Techniques: Injection Routes & Angles Intradermal (ID) 1015 just under the skin (dermis) Subcutaneous (SC) 45 into fat Intravenous (IV) 25