Elevated glutathione levels may reflect an accumulation resulting from impaired recycling, often due to deficiencies in NADPH, selenium, or riboflavin (vitamin B2). This indicates a disruption in the redox balance rather than Redox regulation in lifespan determination Journal of Biological Chemistry Glutathione: The Master Antioxidant Core Med Science Synergistic effects of exogenous glutathione and calcium on ascorbateglutathione cycle and glutathione associated enzymes upregulation under lead stress in Brassica napus L Environmental Science and Pollution Research Springer Nature Link