Sex differences in glutathione metabolism and acetaminophen toxicity Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome Scientific Reports In patients with liver disease, acetaminophen metabolism is altered: the half life may be prolonged, and glutathione stores may be reduced, Therefore, acetaminophen can be used safely at reduced doses The Role of Glutathione in the Management of Cell Mediated Immune Responses in Individuals with HIV