Introduction GHK Cu is a copper peptide complex formed from the tripeptide glycyl L histidyl L lysine bound to copper. This compound has garnered significant attention in both laboratory and formulation research due to its critical role PeerJ The function and mechanisms of action of lysyl oxidase like 3 (LOXL3) in cancers Carcinoma associated fibroblast derived lysyl oxidase rich extracellular vesicles mediate collagen crosslinking and promote epithelial mesenchymal transition via p FAK p paxillin YAP signaling International Journal of Oral Science Enhancement of collagen deposition and cross linking by coupling lysyl oxidase with bone morphogenetic protein 1 and its application in tissue engineering Scientific Reports