B12 Shots at Home: How, Where & How Often to Inject Yourself AZ IV Medics Subcutaneous (SC) and Intramuscular (IM) Injections Must Knows for Subcutaneous administration: Pinch skin with non dominant hand and hold syringe with dominant hand Always inject: 2 inches away from umbilicus (for abdomen) 3 inches Intramuscular injection is shown at 90 because the goal is to reach the muscle, the deepest layer in this comparison. That route is chosen when medication needs reliable absorption through the muscle's Injecting B12 Enhance Me Training Academy