Most people hear not FDA approved and immediately think unsafe or ineffective but the reality is a lot more about economics than science. If something can't be patented, there's little incentive to Impact of Manufacturing Process and Compounding on Properties and Quality of Follow On GLP 1 Polypeptide Drugs Pharmaceutical Research Springer Nature Link The FDA just announced that they're taking steps to lift restrictions on 12 peptides including BPC 157 and TB 500 making them accessible through compounding pharmacies again. This is a HUGE step Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance Sports Medicine Springer Nature Link