Amide Bond Activation of Biological Molecules Condensation and Hydrolysis Reactions (M12Q6) CHEM 104: Working Copy Reactions of Amides a) Hydrolysis Amides can break back into the acid and amine when heated with: Strong acid Strong base Example: Amide + HO Carboxylic acid + Amine b) Reduction Mechanistic investigations of the hydrolysis of amides, oxoesters and thioesters via kinetic isotope effects and positional isotope exchange ScienceDirect
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dihexa amide hydrolysis Amide Hydrolysis: Acid and Base Catalysed Mechanism Explained