When semaglutide and tirzepatide stop working for patients, Im adding in cagrilintide. Cagrilintide can add as much as 9% more weight loss to already used GLP1s such as semaglutide, tirzepatide or Cagrilintide, an amylin analogue, is a promising medication for weight loss by enhancing satiety, delaying gastric emptying, and suppressing appetite. In my patients, I have also seen increased Retatrutide vs. Tirzepatide Best Weight Loss Peptide? Switching to Tirzepatide 5 mg From Glucagon Like Peptide 1 Receptor Agonists: Clinical Expectations in the First 12 Weeks of Treatment Endocrine Practice