Tylenol depletes glutathione your livers most important protective antioxidant. Every dose chips away at it., So instead of taking lower doses every 46 hours, I recommend spacing to 1000mg every 8 Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Use Only as Directed ProPublica