Supplements and chronic pain: What does the research say? Some studies suggest possible benefits for: Acetyl L Carnitine (energy for cells; studied in diabetic nerve pain) Alpha Lipoic Acid (antioxidant; may ease nerve pain, A carnitine transporter at the bloodbrain barrier modulates sleep via glial lipid metabolism in Drosophila PNAS Melatonin & the Heart Melatonin is widely used to improve sleep and regulate circadian rhythm, but it may also affect heart rate, blood pressure, and autonomic tone. While often safe, case reports L Carnitine Linus Pauling Institute Oregon State University