Oncology Letters Item Parental high ARA levels are associated with differential expression of genes involved in methionine cycle, transsulfuration pathway, and glutamate and glutathione metabolism in male F1 livers. Public Library of Full article: Reaction of Carbon Monoxide with Cystathionine Synthase: Implications on Drug Efficacies in Cancer Chemotherapy Fat burning is not always the problem. Sometimes the issue is detox capacity. When you move into a carnivore or animal based diet, the body relies heavily on a pathway called transsulfuration.