Tylenol (acetaminophen) is one of the most commonly used painkillers. It is safe for kids, during pregnancy, and while breastfeeding. However, just because it is safe, doesn't mean that it Acetaminophen & the kidney Renal Fellow Network Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.