Peptides are having a moment. Influencers and wellness clinic doctors are selling experimental peptides as the next biohacking frontier for muscle, recovery, sleep, libido, longevity, you name it. CJC 1295. Ipamorelin. BPC 157. Identification, characterization, and structure activity relationship of the ASIC3 selective peptide WRPRFa Communications Chemistry Attenuation of Response to Repeated Drug Administration: A Proposal for Differentiating Tachyphylaxis and Tolerance The Journal of Pharmacology and Experimental Therapeutics 2021A12 Define the terms tolerance and tachyphylaxis. Discuss the different mechanisms by which tolerance can develop, giving examples where appropriate.