Gender specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen Scientific Reports Taking Ibuprofen? Protect Your Health With These Tips Dr. Green Mom Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Drugs for Pain, Inflammation, and Arthritic Disorders Basicmedical Key