Tylenol depletes something called glutathione. Glutathione is a master antioxidant and your first line of protection against environmental toxins. It detoxifies and protects your cells. It protects your immune system and Liver injury induced by paracetamol and challenges associated with intentional and unintentional use The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism William Parker, Chi Dang Hornik, Staci Bilbo, Zoie E. Holzknecht, Lauren Gentry, View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine