c Met (HGF Receptor) Sino Biological Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted HGF c Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR NGF axis Cell Death & Disease Recent Progress and Advances in HGF MET Targeted Therapeutic Agents for Cancer Treatment