Do B12 Injections Hurt? Painful Shots No More PA Relief Vitamin B12 Injections for Aging and Longevity InVita Wellness The look of surprise never gets old when we do B12 injections and it doesnt hurt , B12 is a great vitamin to increase energy, reduce fatigue, improve nerve function, and so much more! Thank you to Lets do my first B12 injection together This is something Ive been nervous about for a long time, but today I finally did itand it honestly wasnt bad at all. I used the Union Medico needle guide