Tylenol depletes glutathione your liver's most important protective antioxidant. Every dose chips away at it. So instead of taking lower doses every 46 hours, I recommend spacing to 1000mg every 8 hours. Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums