Glutathione Benefits for Skin: Brightening, Anti Aging, and More Glutathione is a natural antioxidant your body makes, and it can influence melanin production which is why it's sometimes marketed for skin brightening. Oral supplements are mostly broken down in the Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Glutathione deficiency and heart failure: a systematic review of human and animal evidence ScienceDirect