MTHFR gene polymorphisms in diabetes mellitus ScienceDirect Methylenetetrahydrofolate reductase (MTHFR) 677C>T rs1801133 genetic variant, homocysteine, folate, and vitamin B12 levels in patients with multiple sclerosis: a scoping review ScienceDirect Replying to @brandielorenmakie the MTHFR gene actually has NOTHING to do WITH detoxing, glutathione or vaccines. Also has nothing to do with sugar bugs, sacral dimples, tongue ties and has no The detox gene (MTHFR) is rendered inactive when your diet is high in meat. Our diet should be 80% plant based or higher.