Your Complete Guide to Glutathione Schoenwalder Health & Wellness Maturation Dependent Vulnerability of Oligodendrocytes to Oxidative Stress Induced Death Caused by Glutathione Depletion Journal of Neuroscience Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.