GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Acetaminophen metabolism and NAPQI mediated mitochondrial effects Download Scientific Diagram 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins.
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glutathione napqi Metabolic pathway for NAPQI formation and detoxification by conjugation...