Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine dependent manner Thorax Smoking cigarettes has long been proven to cause severe lung damage, including chronic obstructive pulmonary disease (COPD), emphysema, and lung cancer. Over time, cigarette smoke destroys lung tissue, fills airways with tar, Journal of the COPD Foundation Journal ClubElectronic Cigarettes and Vaping as a Harm Reduction Alternative: Really? American Thoracic Society Exacerbation of COPD